[Long-term changes in left ventricular function following intracoronary stem cell transplantation for acute myocardial infarction]. / Evolución a largo plazo de la función ventricular tras la terapia celular intracoronaria en el infarto agudo de miocardio.
Rev Esp Cardiol
; 64(4): 334-7, 2011 Apr.
Article
em Es
| MEDLINE
| ID: mdl-21411206
ABSTRACT
Controversy surrounds the long-term effects of intracoronary bone marrow stem cell transplantation after ST-elevation acute myocardial infarction (STEAMI). We report on the long-term changes in left ventricular function observed in 29 patients with STEAMI who were treated using this technique. Cardiac magnetic resonance imaging was performed at baseline, 6 months after transplantation, and long-term follow-up (median 27 months, interquartile range 24-35 months). The left ventricular ejection fraction had improved significantly by 6 months (from 47.6 ± 8.9% to 52.7 ± 11.6%; P = .001) and this improvement was maintained long-term, at 52.4 ± 11.8% (P = .01 vs. baseline and P = .999 vs. 6 months). There was no significant change from baseline in end-diastolic or end-systolic ventricular volume. Our findings indicate the improvement in injection fraction occurs soon after stem cell transplantation, within the first 6 months, and remains unchanged at long-term follow-up.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Função Ventricular Esquerda
/
Transplante de Medula Óssea
/
Vasos Coronários
/
Infarto do Miocárdio
Idioma:
Es
Ano de publicação:
2011
Tipo de documento:
Article