Plasminogen activator inhibitor type-1 gene 4G/5G polymorphism and polycystic ovary syndrome.
Genet Test Mol Biomarkers
; 15(7-8): 565-7, 2011.
Article
em En
| MEDLINE
| ID: mdl-21413876
ABSTRACT
AIM:
This study was conducted in Turkish patients with polycystic ovary syndrome (PCOS) to determine the frequency of 4G/5G polymorphism genotypes of plasminogen activator inhibitor type-1 gene and to examine the role of this polymorphism in PCOS development. MATERIALS ANDMETHODS:
Genomic DNA obtained from 200 persons (100 patients with PCOS and 100 healthy controls) was used in the study. DNA was amplified by polymerase chain reaction using 4G and 5G allele-specific primers. Polymerase chain reaction products were assessed with charged-couple device camera after exposing to 2% agarose gel electrophoresis.RESULTS:
No statistically significant difference between the groups with respect to genotype distribution was found (p>0.05) in the study. The 4G and 5G allele frequencies were indicated as 51.5% and 48.5% in patients, respectively, whereas this was 51%-49% in the control group.CONCLUSION:
Consequently, it has been established by this study that the 4G/5G polymorphism genotypes of plasminogen activator inhibitor type-1 gene do not play a role in the development of PCOS in the Turkish population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Polimorfismo Genético
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Inibidor 1 de Ativador de Plasminogênio
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Predisposição Genética para Doença
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article