Endothelin and hepatic wound healing.
Pharmacol Res
; 63(6): 512-8, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21421048
ABSTRACT
Liver wound healing is a coordinated response to injury caused by infections (hepatitis) or toxins (alcohol) or other processes where activation of hepatic stellate cells are a central component. During stellate cell activation, a major phenotypic transformation occurs which leads to increased production of increased extracellular matrix proteins and smooth muscle α-actin the results is organ dysfunction due to gross architectural disruption and impaired blood flow. Endothelin-1 (ET-1) is produced in increased amounts and the cellular source of ET-1 shifts from endothelial cells to stellate cells during liver injury thus setting a feedback loop which accentuates further activation, stellate cell proliferation, and production of extracellular matrix proteins. Therapy directed at intervening the ET-1 signaling pathway has significant therapeutic potential in patients with liver disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Endotelina-1
/
Fígado
/
Hepatopatias
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article