Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents.
Eur J Med Chem
; 46(6): 2117-31, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21435753
ABSTRACT
Benzo[c]phenanthrolines and benzo[c]phenanthrolinones substituted by dialkylaminoalkyl side chains at position N5 and C6, respectively, were synthesised and their biological activity evaluated. They displayed interessant cytotoxicity associated with some DNA interactions. However, the low topoisomerase 1 affinity suggests that other cellular targets are responsible for the antiproliferative activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenantrolinas
/
Inibidores da Topoisomerase I
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Inibidores da Topoisomerase II
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Antineoplásicos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article