[Simplification to lopinavir/ritonavir monotherapy in HIV-infected children]. / Simplificación a monoterapia con lopinavir/ritonavir en niños infectados por el virus de la inmunodeficiencia humana.

Lopinavir/ritonavir monotherapy as a simplification strategy has the potential to minimize antiretroviral treatment toxicity without losing efficacy in selected cases, according to studies in adults, but little is known in paediatric patients. We report 5 children on this regimen for a median time of 112 weeks. One child with suboptimal adherence required intensification therapy to re-suppress viral load. Randomised controlled trials are needed to evaluate the efficacy of this strategy in children in order to make appropriate recommendations.