The NKT cell ligand αgalactosylceramide suppresses allergic airway inflammation by induction of a Th1 response.
Vaccine
; 29(25): 4249-55, 2011 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-21463684
ABSTRACT
One experimental approach for the treatment of allergic reactions is the stimulation of immunoregulatory NKT cells with the synthetic glycolipid αgalactosylceramide. For a first evaluation of the immunomodulatory potential of αGalCerMPEG a human in vitro allergy model was exploited. Acting as an adjuvant, the glycolipid induced an enhanced Th1-biased allergen-specific immune response of autologous lymphocytes. In a mouse model of allergic airway inflammation, αGalCerMPEG-activated NKT cells promoted a cytokine environment in the spleen, leading to priming of Th1 cells. The shift towards a Th1-dominated allergen-specific immune response thus might mediate the abrogation of allergic airway inflammation and thereby might provide a valid option for therapeutic intervention.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Células Th1
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Células T Matadoras Naturais
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Galactosilceramidas
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Hipersensibilidade
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Fatores Imunológicos
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Inflamação
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article