Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.
Cancer Cell
; 19(4): 484-97, 2011 Apr 12.
Article
em En
| MEDLINE
| ID: mdl-21481790
ABSTRACT
To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Conformation Capture on Chip (4C) method. Two T-ALL subtypes were identified that lacked rearrangements of known oncogenes. One subtype associated with cortical arrest, expression of cell cycle genes, and ectopic NKX2-1 or NKX2-2 expression for which rearrangements were identified. The second subtype associated with immature T cell development and high expression of the MEF2C transcription factor as consequence of rearrangements of MEF2C, transcription factors that target MEF2C, or MEF2C-associated cofactors. We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements.
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Base de dados:
MEDLINE
Assunto principal:
Oncogenes
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Fatores de Transcrição
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Transcrição Gênica
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Proteínas Nucleares
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Genoma Humano
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Fatores de Regulação Miogênica
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Proteínas de Homeodomínio
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Proteínas de Domínio MADS
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Leucemia-Linfoma Linfoblástico de Células T Precursoras
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article