Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins.
Bioorg Med Chem Lett
; 21(10): 3017-20, 2011 May 15.
Article
em En
| MEDLINE
| ID: mdl-21482109
ABSTRACT
The manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines namely Colon HCT-15; Liver Hep-2; Lung A-549 and Leukemia THP-1 at 10 and 100 µM concentrations. The active compounds based on preliminary studies were evaluated for their IC(50) value against six cell lines viz. Colo-205, HCT-15 (Colon), THP-1 (Leukemia), A-549 (Lung), PC-3 (Prostate) and HeLa (Cervix). The active analogue IS-4 exhibited IC(50) values of 4.57, 10.90, 11.75, 12.40 and 54.20 µM against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively.
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1
Base de dados:
MEDLINE
Assunto principal:
Isatina
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article