The synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid hepatitis C virus polymerase NS5B inhibitors.
Bioorg Med Chem Lett
; 21(10): 2869-72, 2011 May 15.
Article
em En
| MEDLINE
| ID: mdl-21507645
ABSTRACT
Herein we report the identification and evaluation of a novel series of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid derivatives identified from a deannulation study performed on the reported benzimidazole NS5B inhibitor, 1. This resulted in the identification of (E)-3-(2-(4-((4'-cyano-4-(4-hydroxypiperidine-1-carbonyl)biphenyl-2-yl)methoxy)phenyl)-1-cyclohexyl-1H-imidazol-4-yl)-2-methylacrylic acid (11) as a potent inhibitor of NS5B. Potential pathways for the further optimization of this series are suggested.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Proteínas não Estruturais Virais
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Hepacivirus
/
Metacrilatos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article