Stonefish antivenom neutralises the inflammatory and cardiovascular effects induced by scorpionfish Scorpaena plumieri venom.
Toxicon
; 57(7-8): 992-9, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21510970
Venomous fish are often involved in human accidents and symptoms of envenomation include local (intense pain and swelling) and systemic effects (cardiovascular and neurological disorders). However the only commercially available antivenom is against the Indo-Pacific stonefish Synanceja trachynisStonefish Antivenom (SFAV). The aim of the present study was to evaluate the potential of SFAV in neutralising the in vivo effects of some toxic activities of scorpionfish Scorpaena plumieri venom (SpV), and the in vitro immuno cross-reactivity. The SpV (7.5-100 µg/animal) caused nociceptive and dose-dependent edematogenic responses in the mice footpad. In rats SpV (300 µg/kg, i.v.) produced immediate and transient increase in arterial blood pressure and decrease in heart rate. Prior incubation of SpV with SFAV (1 µg SpV/1 U SFAV) abolished the inflammatory response, and significantly attenuated the cardiovascular effects induced by SPV. Western blotting analysis on two-dimensional SDS-PAGE of S plumieri venom proteins using SFAV proved that the epitopes recognized by SFAV are shared with the â¼98 kDa proteins. This is the first report of venom similarities between Indo-Pacific and Atlantic venomous fish, suggesting that the SpV compound responsible for inflammatory and cardiovascular effects possesses similar biochemical and antigenic properties to those found in stonefish venom.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peixes Venenosos
/
Antivenenos
/
Doenças Cardiovasculares
/
Venenos de Peixe
/
Inflamação
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article