PicXAA-Web: a web-based platform for non-progressive maximum expected accuracy alignment of multiple biological sequences.
Nucleic Acids Res
; 39(Web Server issue): W8-12, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21515632
ABSTRACT
In this article, we introduce PicXAA-Web, a web-based platform for accurate probabilistic alignment of multiple biological sequences. The core of PicXAA-Web consists of PicXAA, a multiple protein/DNA sequence alignment algorithm, and PicXAA-R, an extension of PicXAA for structural alignment of RNA sequences. Both PicXAA and PicXAA-R are probabilistic non-progressive alignment algorithms that aim to find the optimal alignment of multiple biological sequences by maximizing the expected accuracy. PicXAA and PicXAA-R greedily build up the alignment from sequence regions with high local similarity, thereby yielding an accurate global alignment that effectively captures local similarities among sequences. PicXAA-Web integrates these two algorithms in a user-friendly web platform for accurate alignment and analysis of multiple protein, DNA and RNA sequences. PicXAA-Web can be freely accessed at http//gsp.tamu.edu/picxaa/.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Software
/
Alinhamento de Sequência
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article