Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells.
Int J Cancer
; 129(4): 820-31, 2011 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-21520032
ABSTRACT
Energy metabolism is the foundation of survival for all organisms, and mitochondria are the most important energy-supplying organelles in eukaryotic cells. However, the mitochondrial and energy/metabolism-related properties of cancer stem cells (CSCs), the stem cell-like subpopulation in tumor masses, remain unknown. In our study, we compared the masses of mitochondria and mitochondrial DNA (mtDNA), the mitochondrial membrane potential (Δψm), oxygen/glucose consumption, and the concentration of reactive oxygen species (ROS) and ATP between lung CSCs (LCSCs) and non-LCSCs. In addition, the change in features during differentiation was examined. Some mitochondrial and energy metabolism-related properties, such as perinuclear mitochondrial distribution, a lower quantity of mtDNA, higher Δψm, lower oxygen/glucose consumption, and lower intracellular concentrations of ROS and ATP, can be used as indicators of LCSCs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
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Espécies Reativas de Oxigênio
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Metabolismo Energético
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Potencial da Membrana Mitocondrial
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Neoplasias Pulmonares
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Mitocôndrias
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article