Assessment of the pathway of apoptosis involving PAR-4, DAXX and ZIPK proteins in CLL patients and its relationship with the principal prognostic factors.
Folia Histochem Cytobiol
; 49(1): 98-103, 2011.
Article
em En
| MEDLINE
| ID: mdl-21526495
ABSTRACT
Par-4 (prostate apoptosis response-4) protein was originally found upregulated in prostate tumor cells undergoing apoptosis. Then it was further identified as a proapoptotic protein upregulated both in normal and leukemic lymphocytes. The aim of our study was to assess PAR-4 protein expression in the B cells of CLL patients and to examine its relationship with the expression of other proteins involved in the apoptosis process, such as DAXX, ZIPK and BCL-2. We found a positive relationship between PAR-4 and BCL-2 protein expression. Additionally, there was a positive correlation between PAR-4 and both DAXX and ZIPK protein expression. The results of our research were also analyzed in association with the principal CLL prognostic factors. There was a positive correlation between the expression of PAR-4 protein and the lactate dehydrogenase (LDH) serum concentration (p < 0.005). The expression of PAR-4 protein in B cells correlated positively with the percentage of CD38(+) cells (p < 0.05), as well as with CD38(+)/ZAP-70(+) cells (p < 0.05). Moreover, we found a close relationship between LPL protein expression or LPL/ADAM29 MFI ratio and PAR-4 protein expression. Our results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between PAR-4 expression and the clinical course of the disease. This however requires further investigation.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
/
Leucemia Linfocítica Crônica de Células B
/
Biomarcadores Tumorais
/
Apoptose
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MAP Quinase Quinase Quinases
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Proteínas Adaptadoras de Transdução de Sinal
/
Proteínas Reguladoras de Apoptose
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article