Stress increases VCAM-1 expression at the fetomaternal interface in an abortion-prone mouse model.
J Reprod Immunol
; 89(2): 207-11, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21529964
ABSTRACT
Sound stress exposure increases fetal loss via inflammatory pathways. Inflammation is known to up-regulate cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), which mediates the adhesion of leukocytes to the vascular endothelium. In this work, we studied the frequency of VCAM-1(+) vessels at the fetomaternal interface in stressed and non-stressed pregnant CBA/J female mice mated with DBA/2J (high fetal loss model) or BALB/c (low fetal loss model) males. The high fetal loss model had fewer large vessels on gestation day 6.5, and stress reduced the frequency of large vessels to a similar number in both high and low fetal loss models. In the high fetal loss model, however, the frequency of VCAM-1+ vessels was dramatically increased. This study shows that VCAM-1 expression is modulated by stress at the fetomaternal interface in abortion-prone cross-breeding.
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Base de dados:
MEDLINE
Assunto principal:
Placenta
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Estresse Fisiológico
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Aborto Espontâneo
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Regulação da Expressão Gênica
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Molécula 1 de Adesão de Célula Vascular
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article