Recovery of colonic transit following extrinsic nerve damage in rats.
Scand J Gastroenterol
; 46(6): 678-83, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21561284
ABSTRACT
INTRODUCTION:
Injury to pelvic sympathetic and parasympathetic nerves from surgical and obstetrical trauma has long been cited as a cause for abnormal colorectal motility in humans. Using a rat model, acute transaction of these extrinsic nerves has been shown to effect colorectal motility. The aim of this study is to determine in a rat model how transection of these extrinsic nerves affects colonic transit over time.METHODS:
Eighty-two Sprague-Dawley rats underwent placement of a tunneled catheter into the proximal colon. Bilateral hypogastric, pelvic nerves (HGN and PN) or both were transected in 66 rats. The remaining 16 rats received a sham operation. Colonic transit was evaluated at postoperative days (PODs) 1, 3, and 7 by injecting and calculating the geometric center (GC) of the distribution of (51)Cr after 3 h of propagation.RESULTS:
At POD 1, transection of PNs significantly delayed colonic transit (GC = 4.9, p < 0.05), while transection of HGNs (GC = 8.5, p < 0.05) or transection of both nerves (GC = 7.8, p < 0.05) significantly accelerated colonic transit, when compared with sham operation (GC = 6.0). A significant trend toward recovery was noted in both the HGN and PN transection groups at POD 7.CONCLUSIONS:
Damage to the extrinsic sympathetic and/or parasympathetic PNs affects colonic transit acutely. These changes in large bowel motor function normalize over time implicating a compensatory mechanism within the bowel itself.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Parassimpático
/
Trânsito Gastrointestinal
/
Colo
/
Traumatismos do Sistema Nervoso
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Plexo Hipogástrico
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article