Functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters in the apical canalicular membrane associated with acid secretion.
Biol Pharm Bull
; 34(6): 813-6, 2011.
Article
em En
| MEDLINE
| ID: mdl-21628877
The parietal cell of the gastric gland is a highly differentiated cell responsible for the gastric hydrochloric acid secretion into the lumen of the stomach. In response to stimulation of acid secretion, the parietal cells undergo well-characterized morphological transformations to recruit Hâº/Kâº-ATPase from the cytoplasmic tubulovesicles to the apical canalicular membrane. Besides H⺠extrusion via Hâº/Kâº-ATPase, Clâ» efflux and K⺠recycling across the apical canalicular membrane are necessary via chloride and potassium channels/transporters, respectively. In the last decade, a number of molecular candidates for the Clâ» efflux and K⺠recycling have been identified in the apical canalicular membrane of the parietal cell. This review focuses on the functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters expressed in the apical canalicular membrane associated with gastric acid secretion.
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Base de dados:
MEDLINE
Assunto principal:
Células Parietais Gástricas
/
Polaridade Celular
/
Bombas de Íon
/
Estruturas da Membrana Celular
/
Via Secretória
/
Ácido Gástrico
/
Canais Iônicos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article