Identification of a naturally occurring quinazolin-4(3H)-one firefly luciferase inhibitor.
J Nat Prod
; 74(6): 1500-2, 2011 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-21639131
ABSTRACT
A prefractionated Streptomyces-derived extract was initially identified as being active using a luciferase-based AMP-activated protein kinase (AMPK) assay. Bioassay-guided fractionation led to the isolation of the new compound quinazolin-4(3H)-one (1) as the active component. However, 1 was shown to have potent firefly luciferase inhibitory activity with no effect on AMPK. This is the first report of a natural luciferase inhibitor.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Produtos Biológicos
/
Luciferases de Vaga-Lume
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Quinazolinonas
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Proteínas Quinases Ativadas por AMP
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article