Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors.
J Med Chem
; 54(14): 5265-9, 2011 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-21675776
ABSTRACT
We report the synthesis of new chemical probes (1a,b, 2a-c, 3a-c) based on the structure of the main endocannabinoids for their use in biological systems directly or via click chemistry. As proof of concept, 2-arachidonyl glyceryl ether based biotinylated 3b enables direct visualization of CB(1) receptor in cells. These results represent the starting point for the development of advanced small molecule chemical probes able to generate valuable information about the cannabinoid receptors.
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Base de dados:
MEDLINE
Assunto principal:
Sondas Moleculares
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Receptor CB1 de Canabinoide
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Receptor CB2 de Canabinoide
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Endocanabinoides
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Moduladores de Receptores de Canabinoides
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article