Synthesis of collagenase-sensitive polyureas for ligament tissue engineering.
Macromol Biosci
; 11(8): 1020-30, 2011 Aug 11.
Article
em En
| MEDLINE
| ID: mdl-21681959
ABSTRACT
Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Materiais Biocompatíveis
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Colágeno
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Colagenases
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Engenharia Tecidual
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Regeneração Tecidual Guiada
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Alicerces Teciduais
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article