Ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity.
Neurochem Res
; 36(11): 2127-35, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21706374
ABSTRACT
To clarify the neuroprotective property of ceruloplasmin and the pathogenesis of aceruloplasminemia, we generated ceruloplasmin-deficient (CPâ»/â») mice on the C57BL/10 genetic background and further treated them with a mitochondrial complex I inhibitor, rotenone. There was no iron accumulation in the brains of CPâ»/â» mice at least up to 60 weeks of age. Without rotenone treatment, CPâ»/â» mice showed slight motor dysfunction compared with CPâº/⺠mice, but there were no detectable differences in the levels of oxidative stress markers between these two groups. A low dose of rotenone did not affect the mitochondrial complex I activity in our mice, however, it caused a significant change in motor behavior, neuropathology, or the levels of oxidative stress markers in CPâ»/â» mice, but not in CPâº/⺠mice. Our data support that ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity, probably through its antioxidant properties independently of its function of iron metabolism.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rotenona
/
Ceruloplasmina
/
Estresse Oxidativo
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Síndromes Neurotóxicas
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article