Elephantopus scaber inhibits lipopolysaccharide-induced liver injury by suppression of signaling pathways in rats.
Am J Chin Med
; 39(4): 705-17, 2011.
Article
em En
| MEDLINE
| ID: mdl-21721151
ABSTRACT
Elephantopus scaber (ES, Teng-Khia-U) has been traditionally used for the treatment of nephritis, pain, and fever; however, the direct evidence is lacking. We investigated the effect of ES on lipopolysaccharide (LPS) induced inflammation of BV-2 microglial cells and acute liver injury in Sprague-Dawley (SD) rats. Our results showed that ES reduced LPS-induced nitric oxide (NO), interleukin (IL)-1, IL-6, reactive oxygen species (ROS), and prostaglandin (PGE(2)) production in BV-2 cells. ES significantly decreased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in LPS-treated rats. Furthermore, the water extract, but not the ethanol extract, of ES dose-dependently inhibited LPS-induced JNK, p38 mitogen-activated protein kinases (MAPK), and slightly inhibited cyclooxygenase (COX-2) in BV-2 cells but decreased p38 MAPK and COX-2 expressions in the liver of LPS-treated rats. Taken together, these results indicate that the protective mechanism of ES involves an antioxidant effect and inhibition of p38 MAP kinase and COX-2 expressions in LPS-stressed acute hepatic injury in SD rats.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Anti-Inflamatórios não Esteroides
/
Asteraceae
/
Doença Hepática Induzida por Substâncias e Drogas
/
Inflamação
/
Fitoterapia
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article