A DNA vaccine against ERBB2 impairs chemical carcinogenesis in random-bred hamsters.
Cancer Prev Res (Phila)
; 4(7): 994-1001, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21733823
ABSTRACT
Vaccines against oncoantigens halt early neoplastic lesions in several cancer-prone, genetically engineered mouse models, whereas their ability to prevent chemical carcinogenesis has not been explored. This is a significant issue, as exposure to chemical mutagens is responsible for a substantial percentage of cancers worldwide. Here, we show that the archetypal oncoantigen ERBB2 is transiently overexpressed in Syrian hamsters during the early stages of 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral carcinogenesis. Repeated DNA vaccinations against ERBB2 significantly reduce the number, size, and severity of oral lesions in a manner directly proportional to the anti-ERBB2 antibody response. These results support the prospects of vaccines as a fresh strategy in the management of individuals at risk for exposure to defined carcinogenic agents.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
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Carcinógenos
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Carcinoma de Células Escamosas
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Receptor ErbB-2
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Vacinas de DNA
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9,10-Dimetil-1,2-benzantraceno
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article