Role of mu-opioids as cofactors in human immunodeficiency virus type 1 disease progression and neuropathogenesis.
J Neurovirol
; 17(4): 291-302, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21735315
ABSTRACT
About one third of acquired immunodeficiency syndrome cases in the USA have been attributed to the use of injected addictive drugs, frequently involving opioids like heroin and morphine, establishing them as significant predisposing risk factors for contracting human immunodeficiency virus type 1 (HIV-1). Accumulating evidence from in vitro and in vivo experimental systems indicates that opioids act in concert with HIV-1 proteins to exacerbate dysregulation of neural and immune cell function and survival through diverse molecular mechanisms. In contrast, the impact of opioid exposure and withdrawal on the viral life cycle and HIV-1 disease progression itself is unclear, with conflicting reports emerging from the simian immunodeficiency virus and simian-human immunodeficiency virus infection models. However, these studies suggest a potential role of opioids in elevated viral production. Because human microglia, astrocytes, CD4+ T lymphocytes, and monocyte-derived macrophages express opioid receptors, it is likely that intracellular signaling events triggered by morphine facilitate enhancement of HIV-1 infection in these target cell populations. This review highlights the biochemical changes that accompany prolonged exposure to and withdrawal from morphine that synergize with HIV-1 proteins to disrupt normal cellular physiological functions especially within the central nervous system. More importantly, it collates evidence from epidemiological studies, animal models, and heterologous cell systems to propose a mechanistic link between such physiological adaptations and direct modulation of HIV-1 production. Understanding the opioid-HIV-1 interface at the molecular level is vitally important in designing better treatment strategies for HIV-1-infected patients who abuse opioids.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Abstinência a Substâncias
/
Replicação Viral
/
Síndrome da Imunodeficiência Adquirida
/
HIV-1
/
Vírus da Imunodeficiência Símia
/
Analgésicos Opioides
/
Morfina
/
Transtornos Relacionados ao Uso de Opioides
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article