[Blood platelet alpha adrenergic receptors in congestive heart failure. Effects of ACE inhibition]. / I recettori alfa adrenergici piastrinici nello scompenso cardiaco congestizio. Effetti dell'ACE-inibizione.
Recenti Prog Med
; 81(9): 564-7, 1990 Sep.
Article
em It
| MEDLINE
| ID: mdl-2175926
ABSTRACT
Platelet alpha-2-adrenergic receptor number and affinity were examined in 12 patients with class IV NYHA congestive heart failure (CHF) and 10 normal volunteers paired for age and sex. Platelet alpha-2-adrenergic receptor number is significantly decreased in CHF patients (178 +/- 18 fmol/mg prot. vs 282 +/- 21 fmol/mg prot. p less than 0.05). After Captopril treatment (6 weeks) alpha-2-receptor number increased but this increase was not statistically significant (236 +/- 28 fmol/mg prot.). This study supports the hypothesis that increased levels of circulating catecholamines in CHF lead to a decrease in platelet alpha-2-adrenoreceptors. Improved cardiac function following administration of Captopril could lead to a withdrawal of sympathetic tone. Captopril may also interact with sympathetic nervous function.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Captopril
/
Receptores Adrenérgicos alfa
/
Insuficiência Cardíaca
Idioma:
It
Ano de publicação:
1990
Tipo de documento:
Article