Doxorubicin and ifosfamide for high-grade sarcoma during pregnancy.
Cancer Chemother Pharmacol
; 69(2): 357-67, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-21769666
ABSTRACT
PURPOSE:
Doxorubicin and ifosfamide are highly active drugs for the treatment of high-grade sarcomas, but little is known on the optimal management of young patients who develop such malignancies during pregnancy.METHODS:
We report on a single-institution series of patients (n = 9) with high-grade sarcoma diagnosed during the third trimester of pregnancy. Neoadjuvant chemotherapy combining doxorubicin (50 mg/m(2) day 1) and ifosfamide (2.5 g/m(2) days 1-2) with standard mesna rescue every 3 weeks was administered during the third trimester of pregnancy in five patients.RESULTS:
We observed a favourable outcome for both the mother and the offspring in all cases. Maternal and neonatal pharmacokinetic data for ifosfamide were obtained from one patient and did not evidence a transplacental transfer of this drug. The use of other active drugs (cisplatin, etoposide, dactinomycin and cyclophosphamide) in sarcoma during pregnancy is discussed on the basis of a comprehensive review of the English literature.CONCLUSIONS:
In view of this single-centre experience, we suggest that the treatment of high-grade sarcoma during the third trimester of pregnancy should include an adapted regimen tailored to the pharmacological specificities of the pregnant patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Neoplásicas na Gravidez
/
Sarcoma
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Protocolos de Quimioterapia Combinada Antineoplásica
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article