Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles.
Nat Neurosci
; 14(9): 1118-20, 2011 Jul 24.
Article
em En
| MEDLINE
| ID: mdl-21785436
ABSTRACT
The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
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Base de dados:
MEDLINE
Assunto principal:
Córtex Somatossensorial
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Núcleos Talâmicos
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Potenciais de Ação
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Potenciais Somatossensoriais Evocados
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Dispositivos Ópticos
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Neurônios
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article