Torsion of the human left ventricle: experimental analysis and computational modeling.
Prog Biophys Mol Biol
; 107(1): 112-21, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21791224
ABSTRACT
We set a twofold investigation we assess left ventricular (LV) rotation and twist in the human heart through 3D-echocardiographic speckle tracking, and use representative experimental data as benchmark with respect to numerical results obtained by solving our mechanical model of the LV. We aim at new insight into the relationships between myocardial contraction patterns and the overall behavior at the scale of the whole organ. It is concluded that torsional rotation is sensitive to transmural gradients of contractility which is assumed linearly related to action potential duration (APD). Pressure-volume loops and other basic strain measures are not affected by these gradients. Therefore, realistic torsional behavior of human LV may indeed correspond to the electrophysiological and functional differences between endocardial and epicardial cells recently observed in non-failing hearts. Future investigations need now to integrate the mechanical model proposed here with minimal models of human ventricular APD to drive excitation-contraction coupling transmurally.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rotação
/
Simulação por Computador
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Ecocardiografia Tridimensional
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Ventrículos do Coração
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article