Chiral (acyclic diaminocarbene)gold(I)-catalyzed dynamic kinetic asymmetric transformation of propargyl esters.
J Am Chem Soc
; 133(33): 12972-5, 2011 Aug 24.
Article
em En
| MEDLINE
| ID: mdl-21797265
ABSTRACT
A highly enantioselective transformation catalyzed by chiral (acyclic diaminocarbene)gold(I) complexes is reported. The enantioselective synthesis of 2-substituted chromenyl pivalates from racemic phenol-substituted propargyl pivalates was developed. Rearrangement of the substrates in the presence of cationic gold gave allene intermediates, whose cyclization resulted in formation of enantioenriched product through a dynamic kinetic asymmetric transformation.
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Base de dados:
MEDLINE
Assunto principal:
Alcinos
/
Ésteres
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article