First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM.
Antimicrob Agents Chemother
; 55(10): 4912-4, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21807978
ABSTRACT
Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas da Membrana Bacteriana Externa
/
Proteínas Associadas à Resistência a Múltiplos Medicamentos
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Farmacorresistência Bacteriana Múltipla
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Achromobacter denitrificans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article