Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.
Hum Mol Genet
; 20(R2): R109-15, 2011 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-21828073
ABSTRACT
The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts early diagnosis, drug development and effective treatment.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Pluripotentes Induzidas
/
Doenças do Sistema Nervoso
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article