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The genetic blueprint of major depressive disorder: contributions of imaging genetics studies.
Scharinger, Christian; Rabl, Ulrich; Pezawas, Lukas; Kasper, Siegfried.
Afiliação
  • Scharinger C; Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
World J Biol Psychiatry ; 12(7): 474-88, 2011 Oct.
Article em En | MEDLINE | ID: mdl-21830992
OBJECTIVES: To review neuroimaging intermediate phenotypes of MDD and their relation to genetic risk variants. METHODS: A systematic literature search of peer-reviewed English language articels using PubMed ( www.pubmed.org ) was performed. RESULTS: Comprehensive evidence on the influence of serotonergic genes (SLC6A4, HTR1A, MAOA, TPH2) and BDNF on the following neural intermediate phenotypes is displayed: amygdala reactivity, coupling of amygdala-anterior cingulate cortex (ACC) activity, ACC volume, hippocampal volume and serotonin receptor 1A (5-HT1A) binding potential (BP). CONCLUSIONS: Intermediate phenotypes may bridge the gap between genotype and phenotype by reducing the impreciseness of psychiatric phenotypes and yield more insights into the underlying biology.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Neuroimagem Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Neuroimagem Idioma: En Ano de publicação: 2011 Tipo de documento: Article