Bioaccumulation and effects of CdTe/CdS quantum dots on Chlamydomonas reinhardtii - nanoparticles or the free ions?
Environ Sci Technol
; 45(18): 7664-9, 2011 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-21842898
ABSTRACT
In order to properly assess the environmental risk of engineered nanoparticles (ENP), it is necessary to determine their fate (including dissolution, aggregation, and bioaccumulation) under representative environmental conditions. CdTe/CdS quantum dots (QD), such as those used in medical imaging, are known to release Cd(2+) due (mainly) to the dissolution of their outer shell. In this study, Chlamydomonas reinhardtii was exposed to either a soluble Cd salt or QD at similar concentrations of total Cd. Free Cd concentrations were measured using the Absence of Gradients and Nernstian Equilibrium Stripping technique. QD dissolution increased with decreasing pH and with increasing QD concentration. When exposed to QD, bioaccumulation was largely accounted for by dissolved Cd. Nonetheless, QD were shown to be taken up by the cells and to provoke unique biological effects. Whole transcriptome screening using RNA-Seq analysis showed that the free Cd and the QD had distinctly different biological effects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfetos
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Telúrio
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Cádmio
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Chlamydomonas reinhardtii
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Compostos de Cádmio
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Pontos Quânticos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article