In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.
Phytochemistry
; 72(16): 2024-30, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21843897
ABSTRACT
During the course of screening to discover antitrypanosomal compounds, 24 known plant terpenes (6 sesquiterpenes, 14 sesquiterpene lactones and 4 diterpenes) were evaluated for in vitro antitrypanosomal activity against Trypanosoma brucei brucei. Among them, 22 terpenes exhibited antitrypanosomal activity. In particular, α-eudesmol, hinesol, nardosinone and 4-peroxy-1,2,4,5-tetrahydro-α-santonin all exhibited selective and potent antitrypanosomal activities in vitro. Detailed here in an in vitro antitrypanosomal properties and cytotoxicities of the 24 terpenes compared with two therapeutic antitrypanosomal drugs (eflornithine and suramin). This finding represents the first report of promising trypanocidal activity of these terpenes. Present results also provide some valuable insight with regard to structure-activity relationships and the possible mode of action of the compounds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Tripanossomicidas
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Trypanosoma brucei brucei
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article