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Disappearance of malignant cells by effusion drainage alone in two patients with HHV-8-unrelated HIV-negative primary effusion lymphoma-like lymphoma.
Terasaki, Yasushi; Yamamoto, Hiroki; Kiyokawa, Hiroaki; Okumura, Hirokazu; Saito, Katsuhiko; Ichinohasama, Ryo; Ishida, Youichi.
Afiliação
  • Terasaki Y; Division of Internal Medicine, Toyama City Hospital, 2-1, Hokubu-machi, Imaizumi, Toyama, 939-8511, Japan. terasaki@tch.toyama.toyama.jp.
  • Yamamoto H; Division of Internal Medicine, Toyama City Hospital, 2-1, Hokubu-machi, Imaizumi, Toyama, 939-8511, Japan.
  • Kiyokawa H; Division of Internal Medicine, Toyama City Hospital, 2-1, Hokubu-machi, Imaizumi, Toyama, 939-8511, Japan.
  • Okumura H; Division of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan.
  • Saito K; Division of Pathology, Toyama City Hospital, Toyama, Japan.
  • Ichinohasama R; Division of Hematopathology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Ishida Y; Division of Internal Medicine, Toyama City Hospital, 2-1, Hokubu-machi, Imaizumi, Toyama, 939-8511, Japan.
Int J Hematol ; 94(3): 279-284, 2011 Sep.
Article em En | MEDLINE | ID: mdl-21858447
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma usually confined to the body cavities of predominantly immunosuppressed patients infected with human herpes virus-8 (HHV-8). In PEL, malignant cells are usually negative for B-cell markers, such as CD19, CD20, and CD79a, but are positive for activation and plasma cell-related markers, such as CD30, CD38, and CD138. It has been reported that HHV-8-unrelated PEL shows high expression of B-cell markers, which is referred to as PEL-like lymphoma. Here, we report two cases of HHV-8-unrelated HIV-negative PEL-like lymphoma in which malignant cells regressed spontaneously after effusion drainage alone. These cells expressed B-cell markers, such as CD20. No chemotherapy was given to either patient, as they were of an advanced age, and both achieved a complete response by effusion drainage alone. One showed a complete response for 16 months after effusion drainage, and the other has survived for 11 months with a complete response. This suggests that sufficient drainage of serous effusion may induce and maintain a complete response in some patients with HHV-8-unrelated HIV-negative PEL-like lymphoma, which represents an excellent treatment option for elderly patients with this disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Drenagem / Soronegatividade para HIV / Linfoma de Efusão Primária Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Drenagem / Soronegatividade para HIV / Linfoma de Efusão Primária Idioma: En Ano de publicação: 2011 Tipo de documento: Article