[Cardiotropic activity of synthetic peptide CH3CO-Lys-Lys-Arg-Arg-NH2 (protectin)].
Eksp Klin Farmakol
; 74(6): 14-9, 2011.
Article
em Ru
| MEDLINE
| ID: mdl-21870769
ABSTRACT
Peptide CH3CO-Lys-Lys-Arg-Arg-NH2 (protectin) was synthesized and its activity was studied on the model of experimental myocardial infarction in rats in comparison to the reference antihypoxant drug riboxin. Intranasal injections ofprotectin at doses within 2-20 microg/kg once a day by course of 7 days produced a pronounced anti-ischemic action, improved coronary circulation of the blood, increases contractile activity of myocardium, reduced intensity of lipid peroxidation, and improved antioxidant protection. In some respects (improved coronary circulation of the blood, increased antioxidant protection), protectin was more effective than riboxin.
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Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Inosina Difosfato
/
Infarto do Miocárdio
Idioma:
Ru
Ano de publicação:
2011
Tipo de documento:
Article