Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders.
Med Sci Monit
; 17(9): RA215-20, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21873960
Dopamine receptors control neural signals that modulates behavior. Dopamine plays an important role in normal attention; that is the reason for studying the genes of the dopaminergic system, mainly in connection with disorders of attention. DRD4 influences the postsynaptic action of dopamine and is implicated in many neurological processes, exhibits polymorphism and is one of the most studied genes in connection with psychiatric disorders. Associations were found with ADHD (attention deficit hyperactivity disorder), substance dependences, several specific personality traits, and reaction to stress. These findings have implications for pharmacogenetics. This article reviews the principle published associations of DRD4 variants with psychiatric disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
/
Receptores de Dopamina D4
/
Transtornos Mentais
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article