Chip-based drug screening for inhibiting α-glucosidase.
Fitoterapia
; 82(8): 1249-57, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21907768
ABSTRACT
Intestinal α-glucosidase performs a physiologically vital function in the digestive process of dietary carbohydrates. Administration of an α-glucosidase inhibitor may retard the digestion and absorption of carbohydrates. Consequently, the rise in postprandial blood glucose could be suppressed. This study developed a novel technology, called "after flowing through immobilized receptor (AFTIR)," for targeting components in herbal medicines with α-glucosidase-suppressing capability. As a result, we reveal that the AFTIR system is a highly-efficient drug screening platform, capable of purifying and identifying active components with α-glucosidase-suppressing capability in herbal medicines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carboidratos da Dieta
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Extratos Vegetais
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Avaliação Pré-Clínica de Medicamentos
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Inibidores Enzimáticos
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Metabolismo dos Carboidratos
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Inibidores de Glicosídeo Hidrolases
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Hipoglicemiantes
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article