Discovery of pyrazoles as novel FPR1 antagonists.
Bioorg Med Chem Lett
; 21(21): 6456-60, 2011 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-21955939
ABSTRACT
A series of pyrazole inhibitors of the human FPR1 receptor have been identified from high throughput screening. The compounds demonstrate potent inhibition in human neutrophils and attractive physicochemical and in vitro DMPK profiles to be of further interest.
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1
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Receptores de Formil Peptídeo
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article