Effect of zibu shenjing fang (see text) on growth and development of the mouse with kidney-essence insufficiency and study on the mechanism.
J Tradit Chin Med
; 31(3): 232-4, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21977868
ABSTRACT
OBJECTIVE:
To investigate effects of Zibu Shenjing Fang (see text) on growth and development of the mouse with insufficiency ofkidney-essence and the mechanism.METHODS:
Total 50 mice were randomly divided into a normal group, a model group, a Jingui Shenqi Wan (see text) group, a Zibu Shenjing Fang high dose group and a Zibu Shenjing Fang low dose group, 10 mice in each group. The kidney-essence insufficiency mouse model was established by use of threat-injuring the kidney combined with over-fatigue. At the same time of modeling, the mice in the model group were intragastrically administrated with saline 20 mL x kg(-1) x d(-1), in the Jingui Shenqi Wan group with suspension of the Jingui Shenqi Wan 2.7 g x kg(-1) x d(-1), in the Zibu Shenjing Fang high dose group with Zibu Shenjing Fang 20 g x kg(-1) x d(-1) and in the Zibu Shenjing Fang low dose group with Zibu Shenjing Fang 10 g x kg(-1) x d(-1), for 21 consecutive days. The general state was observed, the body weight was weighted, and serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) contents were detected.RESULTS:
Compared with model group, Zibu Shenjing Fang groups and Jingui Shenqi Wan group could improve manifestation of the mouse with kidney-essence insufficiency, increase body weight of the mouse and serum GH and IGF-1 contents, especially in the high dose group.CONCLUSION:
Zibu Shenjing Fang gives play to the function of tonifying the kidney and replenishing essence through regulating GH and IGF-1 levels, so as to influence growth and development of the mouse.
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Insuficiência Renal
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article