Supplementation with all three macular carotenoids: response, stability, and safety.
Invest Ophthalmol Vis Sci
; 52(12): 9207-17, 2011 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-21979997
ABSTRACT
PURPOSE:
This study was designed to investigate serum and macular response to, and safety of supplementation with, meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z), the carotenoids that constitute macular pigment (MP).METHODS:
Forty-four healthy subjects were recruited into this randomized, placebo-controlled, clinical trial. Subjects consumed one tablet per day containing 10.6 mg MZ, 5.9 mg L, and 1.2 mg Z (intervention, I group) or placebo (P group). The spatial profile of MP optical density (MPOD) was measured with customized heterochromatic flicker photometry (cHFP), and serum concentrations of L and Z were quantified by using high performance liquid chromatography (HPLC). Subjects were assessed at baseline and at 3 and 6 months. Clinical pathology analysis was performed at baseline and 6 months.RESULTS:
Serum concentrations of L and Z increased significantly in the I group (P = 0.001 and 0.003, respectively) and remained stable in the P group (P > 0.05). There was a significant increase in central MPOD in the I group (0.25° P = 0.001; 0.5° P = 0.001), with no significant change in the P group (P > 0.05). Clinical pathology analysis confirmed that all variables remained within the normal reference range, with the exception of total cholesterol and low-density lipoprotein (LDL), which exhibited baseline values outside the accepted normal reference range before supplementation.CONCLUSIONS:
Subjects supplemented with MZ, L, and Z exhibited significant increases in serum concentrations of these carotenoids and a subsequent increase in central MPOD. Pathology analysis suggested no adverse clinical implications of consuming these carotenoids. (http//isrctn.org number, ISRCTN60816411).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pigmentos da Retina
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Luteína
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Suplementos Nutricionais
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Xantofilas
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article