Correlation between expression of S100A4 and VEGF-C, and lymph node metastasis and prognosis in gastric carcinoma.
J Int Med Res
; 39(4): 1333-43, 2011.
Article
em En
| MEDLINE
| ID: mdl-21986134
ABSTRACT
This semiquantitative immunohistochemical study investigated the clinical significance of S100A4 and vascular endothelial growth factor C (VEGF-C) protein expression in gastric carcinoma. Correlations between S100A4 and VEGF-C immunoreactivity and clinicopathological characteristics were evaluated using 108 gastric carcinoma specimens and 20 specimens of tissue adjacent to gastric carcinoma. S100A4 and VEGF-C expression in carcinoma was higher than that in adjacent tissues. S100A4 expression was significantly related to tumour size and lymph node metastasis, whereas VEGF-C expression was associated with invasion depth, lymph node metastasis and tumour, node, metastasis (TNM) stage. A significant correlation was found between S100A4 and VEGF-C expression. Patients expressing S100A4 or VEGF-C showed no significant reduction in 5-year survival rate compared with those not expressing these proteins. Sex, age, tumour size, invasion depth, lymph node involvement, TNM stage, S100A4 expression and VEGF-C expression had a common effect on carcinoma prognosis but none was an independent prognostic factor.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Proteínas S100
/
Fator C de Crescimento do Endotélio Vascular
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article