Total synthesis and absolute configuration of avenolide, extracellular factor in Streptomyces avermitilis.
J Antibiot (Tokyo)
; 64(12): 781-7, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21989459
ABSTRACT
The first total synthesis of extracellular factor, "Avenolide", in Streptomyces avermitilis has been achieved using a convergent approach. The stereogenic centers in two key segments were installed using Sharpless epoxidation and dihydroxylation. This synthetic study allowed the determination of the absolute configuration of avenolide as 4S,10R, and yielded important information on its structure-activity relationship.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
4-Butirolactona
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article