Elucidating the functionality of kinesins: an overview of small molecule inhibitors.
Semin Cell Dev Biol
; 22(9): 935-45, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-22001111
ABSTRACT
Kinesin motor proteins are ubiquitously involved in multiple fundamental cellular processes, coordinating transport and mediating changes to cellular architecture. Thus, specific small molecule kinesin inhibitors can shed new light on the functions of kinesins and the dynamic roles in which they participate. Here we review the range of known inhibitors, their key characteristics, and specificity, and discuss their potential suitability for chemical genetics as starting points to further investigate complex kinesin-mediated processes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cinesinas
/
Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article