Newborn neurons in the olfactory bulb selected for long-term survival through olfactory learning are prematurely suppressed when the olfactory memory is erased.
J Neurosci
; 31(42): 14893-8, 2011 Oct 19.
Article
em En
| MEDLINE
| ID: mdl-22016522
ABSTRACT
A role for newborn neurons in olfactory memory has been proposed based on learning-dependent modulation of olfactory bulb neurogenesis in adults. We hypothesized that if newborn neurons support memory, then they should be suppressed by memory erasure. Using an ecological approach in mice, we showed that behaviorally breaking a previously learned odor-reward association prematurely suppressed newborn neurons selected to survive during initial learning. Furthermore, intrabulbar infusions of the caspase pan-inhibitor ZVAD (benzyloxycarbonyl-Val-Ala-Asp) during the behavioral odor-reward extinction prevented newborn neurons death and erasure of the odor-reward association. Newborn neurons thus contribute to the bulbar network plasticity underlying long-term memory.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
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Olfato
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Condicionamento Psicológico
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Neurogênese
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Neurônios
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article