p-fluoro-phenylalanine resistance in Aspergillus nidulans diploid cells: evidence that dominant, lethal mutations are involved.
Curr Genet
; 17(6): 519-22, 1990 Jun.
Article
em En
| MEDLINE
| ID: mdl-2202526
ABSTRACT
An unexpectedly large number of p-fluoro-phenylalanine (FPA)-resistant mutants have been recovered after UV-irradiation of wild type diploid conidia of Aspergillus nidulans. At least five different classes of mutants, possibly corresponding to five different loci, have been identified. Two of them may be the dominant loci which have already been described but the others (a minimum of three loci) are completely different. Mutations in these loci confer high level FPA resistance in the heterozygous diploids, being lethal in the haploids; one mutation has been preliminarily mapped to chromosome I and another to chromosome III.
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Base de dados:
MEDLINE
Assunto principal:
P-Fluorfenilalanina
/
Fenilalanina
/
Aspergillus nidulans
/
Genes Dominantes
/
Genes Letais
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article