Positive impact of long-term antithyroid drug treatment on the outcome of children with Graves' disease: national long-term cohort study.
J Clin Endocrinol Metab
; 97(1): 110-9, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22031519
ABSTRACT
CONTEXT Drug-based therapy is usually the initial treatment for Graves' disease (GD) hyperthyroidism in children, but there is some debate about treatment duration. OBJECTIVE:
Our objective was to assess the effect of long-term carbimazole therapy on GD remission in children and its determinants. DESIGN ANDSETTING:
This was an observational prospective multicenter follow-up cohort study.PARTICIPANTS:
Participants included 154 children newly diagnosed with GD between 1997 and 2002. The intention was to treat patients with three consecutive courses of carbimazole, each lasting 2 yr. Definitive treatment was performed in cases of poor compliance with antithyroid drug (ATD) treatment, thyrotoxicosis relapse, or major adverse effects of ATD treatment. MAIN OUTCOMEMEASURE:
The main outcome measure was remission for at least 18 months after the completion of each course of ATD treatment.RESULTS:
The median duration of follow-up was 10.4 (9.0-12.1) yr. Overall estimated remission rates (95% confidence interval) 18 months after the withdrawal of ATD treatment increased with time and were 20 (13-26), 37 (29-45), 45 (35-54), and 49 (40-57)% after 4, 6, 8, and 10 yr follow-up, respectively. A multivariate competing risk model revealed an independent positive effect of less severe forms of hyperthyroidism at diagnosis [subhazard ratio of 1 for patients with free T(4) <35 pmol/liter vs. 0.4 (0.20-0.80) for free T(4) ≥ 35 pmol/liter; P = 0.01] and of the presence of other autoimmune conditions [subhazard ratio of 2.23 (1.19-4.18); P = 0.01] on remission rate after medical treatment.CONCLUSION:
About half the patients achieved remission after carbimazole discontinuation, and there seems to be a plateau in the incidence of remission achieved after 8-10 yr ATD therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antitireóideos
/
Doença de Graves
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article