Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors.
Nanomedicine
; 8(6): 900-7, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22033084
ABSTRACT
Ultrasound sonication with microbubbles (MBs) has the potential to enhance the delivery of nanoparticles into the sonicated tumors. In this study, we investigated the feasibility of focused ultrasound (FUS) sonication with MBs to improve nanodrug delivery and tumor treatment. Tumor-bearing mice were first injected with MBs (SonoVue) intravenously, were then sonicated at the tumors with FUS sonication, and were finally injected with the PEGylated liposomal doxorubicin (DOX). The accumulation of DOX in tumors with time, the tumor growth responses for initial treated tumor size and DOX dosage, and the response for an additional sonication after DOX injection were studied. The results demonstrate that FUS sonication with MBs can significantly enhance DOX accumulation in the sonicated tumor at 24 hours after treatment. A significant hindrance to tumor growth is achieved for a small tumor with a low dose, whereas large tumors require a higher dose.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
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Sonicação
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Hexafluoreto de Enxofre
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Neoplasias Colorretais
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Doxorrubicina
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Nanocápsulas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article