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Induced oscillatory responses during the Sternberg's visual memory task in patients with Alzheimer's disease and mild cognitive impairment.
Kurimoto, Ryu; Ishii, Ryouhei; Canuet, Leonides; Ikezawa, Koji; Iwase, Masao; Azechi, Michiyo; Aoki, Yasunori; Ikeda, Shunichiro; Yoshida, Tetsuhiko; Takahashi, Hidetoshi; Nakahachi, Takayuki; Kazui, Hiroaki; Takeda, Masatoshi.
Afiliação
  • Kurimoto R; Department of Psychiatry, Osaka University Graduate School of Medicine, 2-2 D3, Yamadaoka, Suita, Osaka 565-0871, Japan.
Neuroimage ; 59(4): 4132-40, 2012 Feb 15.
Article em En | MEDLINE | ID: mdl-22047628
ABSTRACT
In this study we used magnetoencephalography during a modified version of the Sternberg's memory recognition task performed by patients with early Alzheimer's disease (AD), mild cognitive impairment (MCI), and by age-matched healthy controls to identify differences in induced oscillatory responses. For analyses, we focused on the retention period of the working memory task. Multiple-source beamformer and Brain Voyager were used for localization of source-power changes across the cortex and for statistic group analyses, respectively. We found significant differences in oscillatory response during the task, specifically in beta and gamma frequency bands patients with AD showed reduced beta event-related desynchronization (ERD) in the right central area compared to controls, and reduced gamma ERD in the left prefrontal and medial parietal cortex compared to patients with MCI. Our findings suggest that reduced oscillatory responses over certain brain regions in high frequency bands (i.e., beta, gamma), and especially in the beta band that was significantly different between AD patients and healthy subjects, may represent brain electromagnetic changes underlying visual-object working memory dysfunction in early AD, and a neurophysiological indicator of cognitive decline.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Magnetoencefalografia / Córtex Cerebral / Transtornos Cognitivos / Doença de Alzheimer / Memória de Curto Prazo Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Magnetoencefalografia / Córtex Cerebral / Transtornos Cognitivos / Doença de Alzheimer / Memória de Curto Prazo Idioma: En Ano de publicação: 2012 Tipo de documento: Article