Time course of vascular reactivity using repeated phase-contrast MR angiography in patients with carotid artery stenosis.
Stroke
; 43(2): 553-6, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22052518
ABSTRACT
BACKGROUND AND PURPOSE:
Cerebral vascular reactivity assessment is typically performed with 2 perfusion measurements before and after a vasodilatory challenge. The aim of this study was to assess the time course of the vasodilatory effect in the brain-feeding arteries after a challenge with acetazolamide in patients with a stenosis of the internal carotid artery (ICA).METHODS:
Twenty-one patients with a symptomatic ICA stenosis and 18 healthy control subjects underwent 2-dimensional phase-contrast MR angiography to repeatedly measure the blood flow (mL/min) in both ICAs at baseline and in 5-minute intervals for 30 minutes after intravenous administration of acetazolamide.RESULTS:
At baseline, the blood flow was significantly lower in the stenosed ICAs of patients (155 ± 17 mL/min) than in the contralateral ICAs (237 ± 21 mL/min, P<0.05) and the ICAs of healthy control subjects (249 ± 15 mL/min, P<0.05) and remained lower throughout the time course. The maximum vasodilatory effect in the stenosed ICAs was observed after 15.3 ± 0.9 minutes, which was significantly later than in the contralateral ICAs (within 12.9 ± 0.7 minutes, P<0.05) and healthy ICAs (within 12.8 ± 0.8 minutes, P<0.05).CONCLUSIONS:
The onset of the maximum vasodilatory effect after administration of acetazolamide is delayed in patients with a symptomatic ICA stenosis.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Artéria Carótida Interna
/
Estenose das Carótidas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article