Quantitative assessment of skeletal muscle degeneration in patients with myotonic dystrophy type 1 using MRI.
J Magn Reson Imaging
; 35(3): 678-85, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22069222
ABSTRACT
PURPOSE:
To identify MRI biomarkers that could be used to follow disease progression and therapeutic efficacy in one individual muscle in patients with myotonic dystrophy type 1 (DM1). MATERIALS ANDMETHODS:
Lower limb MRI and maximal ankle dorsiflexor strength assessment, using a hand-held dynamometer, were performed in 19 DM1 patients and 6 control subjects. The volume of residual muscle tissue of Tibialis Anterior (TA) muscle was chosen as an index for muscle atrophy, and the T2-relaxation-time of the residual muscle tissue was measured to evaluate edema-like lesions. The fat-to-water ratio was assessed using three-point Dixon images to quantify fat infiltration in the entire muscle.RESULTS:
The intra-observer variability of MRI indices (â¼5.2% for the residual muscle tissue volume and 2.5% for the fat-to-water ratio) was lower than that of the dorsiflexor torque measurement (â¼11.5%). A high correlation (r = 0.91) was found between maximal ankle dorsiflexor strength and residual TA muscle tissue volume in DM1 patients. Increases in the fat-to-water ratio and T2-relaxation-time were associated with a decrease in maximal ankle dorsiflexor strength.CONCLUSION:
MRI appears as a noninvasive method which can be used to follow disease progression and therapeutic efficacy.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Atrofia Muscular
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Músculo Esquelético
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Articulação do Tornozelo
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Distrofia Miotônica
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article